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How long will the side effects of Prolia last?

Medically reviewed by Melisa Puckey, BPharm. Last updated on Feb 7, 2023.

Official answer


The most common side effects of Prolia are fatigue (45%), body weakness and lack of energy (45%), back pain (35%), low phosphate levels (32%), nausea (31%) and diarrhea (20%).

It is difficult to say what will happen with these side effects. Some may go away or get worse or new side effects may develop as treatment goes on. Prolia stays in your body for over 4 months so some of these side effects can last a long time.

Another side effect of Prolia is that it can cause an increase in bone breaks when you stop using it. This increase in fractures can start as early as 7 months after you stop it and can include cracks or breaks of the vertebrae.

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