How long will the side effects of Prolia last?
Medically reviewed by Melisa Puckey, BPharm. Last updated on Feb 17, 2021.

Official Answer
by Drugs.comThe most common side effects of Prolia are fatigue (45%), body weakness and lack of energy (45%), back pain (35%), low phosphate levels (32%), nausea (31%) and diarrhea (20%).
It is difficult to say what will happen with these side effects. Some may go away or get worse or new side effects may develop as treatment goes on. Prolia stays in your body for over 4 months so some of these side effects can last a long time.
Another side effect of Prolia is that it can cause an increase in bone breaks when you stop using it. This increase in fractures can start as early as 7 months after you stop it and can include cracks or breaks of the vertebrae.
For more side effect information click here: https://www.drugs.com/sfx/prolia-side-effects.html
Here's a link to patient reviews of Prolia: https://www.drugs.com/comments/denosumab/prolia-for-osteoporosis.html
References
- SAT0464 Multiple Rebound-associated Vertebral Fractures after Denosumab Discontinuation in Rheumatology Clinic https://ard.bmj.com/content/79/Suppl_1/1189.2
- Prolia Professional Medication Information: https://www.drugs.com/pro/prolia.html
Related Medical Questions
- Does Prolia weaken your immune system?
- Does Prolia increase bone density?
- Xgeva vs Prolia. How do they compare?
- What medications are available to treat osteoporosis?
- How can I prevent osteoporosis?
- How long should you take Xgeva for?
- Is Xgeva a chemotherapy drug?
- Does Xgeva cause bone pain?
- Does Xgeva cause low blood pressure?
Drug Information
- Prolia Information for Consumers
- Prolia Information for Healthcare Professionals (includes dosage details)
- Side Effects of Prolia (detailed)
Related Support Groups
- Prolia (24 questions, 161 members)