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How long does Rhofade take to work?

Medically reviewed by Melisa Puckey, BPharm. Last updated on March 23, 2021.

Official Answer


Rhofade works within 3 hours of first use to reduce facial redness for up to 11.6% of patients. With regular use over one year 36.7% of patients have a 2-grade or greater improvement in redness score, when measured 3 hours after Rhofade has been applied.

The redness measurements were repeated after 4 weeks, 26 weeks and 52 weeks to see how many patients had a 2-grade or greater improvement.

  • At 4 weeks, 3 hours after Rhofade had been applied there was an improvement in redness in 19.5% of patients and after 6 hours this increased to 23% of patients.
  • At 26 weeks, 3 hours after Rhofade was applied an improvement in redness was seen in 34.7% of patients and after 6 hours this increased to 38.1% of patients.
  • At the end of the trial at 52 weeks, 3 hours after the Rhofade had been applied 36.7% of patients had seen an improvement in redness and 6 hours later this had increased to 43.4% of patients.

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