How long does it take Zeposia (ozanimod) to work?
Zeposia (ozanimod) typically begins to provide relief from symptoms of multiple sclerosis within a few months of starting, although it may take up to a year for the full effects to be seen. Zeposia reduces the progression of multiple sclerosis, reduces the number of relapses, and people taking Zeposia had less brain atrophy than others prescribed standard multiple sclerosis care.
- Research has shown that there was a trend towards a reduction in disease progression with ozanimod Vs interferon-beta-1a within 3 months of administration (7.6% of ozanimod patients had disease progression Vs 7.8% of patients assigned interferon, although this difference was not statistically significant)
- After one year of treatment, 78% of patients taking ozanimod were relapse-free, compared with 66% of patients taking interferon-beta-1a. After 2 years 76% of patients taking ozanimod remained relapse-free compared with 64% of those taking interferon
- The number of new or enlarging T2 hyperintense lesions seen on MRI was significantly lower with one year of ozanimod treatment compared to the number seen with interferon (a 48% relative reduction). The number of GdE lesions was also statistically significantly lower with ozanimod compared to interferon (a 63% relative reduction).
- In two year studies, these significant results persisted, although the relative reductions were slightly less (46% for T2 lesions and 53% for GdE lesions).
Zeposia is an oral prescription medicine that is approved to treat relapsing forms of multiple sclerosis (MS) in adults including clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease.
For people with moderately to severely active ulcerative colitis (UC), decreases in rectal bleeding and stool frequency were seen as early as week 2 and significant differences in clinical remission, clinical response, and endoscopic improvement compared to placebo were noted within 10 weeks of starting Zeposia.
- In True North, a phase 3 trial that compared ozanimod to placebo in adult patients with moderately to severely active UC, the primary endpoint of clinical remission was met by week 10 with 18% of people taking ozanimod in remission compared to only 6% of those taking placebo. Secondary endpoints were also met, including clinical response (48% versus 26%), endoscopic improvement (27% versus 12%), and endoscopic-histologic mucosal improvement (13% versus 4%) for ozanimod versus placebo, respectively.
- In the maintenance part of the trial the primary endpoint of clinical remission (37% versus 19%) as well as key secondary endpoints, including clinical response (60% versus 41%), endoscopic improvement (46% versus 26%), corticosteroid-free clinical remission (32% versus 17%) and endoscopic-histologic mucosal improvement (30% versus 14%) for ozanimod versus placebo, respectively, were maintained at week 52.
Related questions
- Is Zeposia (ozanimod) a biologic? How does it work?
- Why does Zeposia (ozanimod) slow down your heart rate?
- What can I eat or drink with ulcerative colitis?
References
- Zeposia Prescribing Information. Revised 08/2024. https://packageinserts.bms.com/pi/pi_zeposia.pdf
Read next
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Flare ups of ulcerative colitis usually last for days or weeks and are unlikely to get better by themselves. Without treatment they can persist for longer, which can cause further damage to the lining of the colon. Ulcerative colitis tends to be a progressive condition which means that as time goes on, flare ups become more frequent and last for longer and periods of remission get shorter. Continue reading
What is the life expectancy of someone with ulcerative colitis?
The life expectancy of people with ulcerative colitis (UC) is usually the same as anybody without the disease if the condition is well managed and treated and complications do not arise if surgery is needed. One cohort study found that people over the age of 50 years who had extensive colitis when they were first diagnosed were more likely to die within the first two years of diagnosis from complications associated with surgery and other coexisting conditions. Continue reading
See also:
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