How is Troxyca ER formulated to be abuse deterrent?
Troxyca ER (oxycodone hydrochloride and naltrexone hydrochloride) capsules contain pellets of oxycodone with a naltrexone core. If the pellets are crushed, the naltrexone blocks the euphoric effects of the oxycodone.
Troxyca ER has been discontinued and is no longer available for use.
What is Troxyca ER?
Troxyca ER is a combination of oxycodone hydrochloride (an opioid agonist) and naltrexone hydrochloride (an opioid antagonist) indicated for the management of pain severe enough to require daily, around-the-clock, long-term opioid treatment and for which alternative treatment options are inadequate.
Troxyca ER is formulated as extended-release capsules. It is a Schedule II controlled substance with a high potential for abuse and and dependence.
How is Troxyca ER Abuse-Deterrent?
Troxyca ER contain pellets that consist of oxycodone hydrochloride with sequestered naltrexone hydrochloride. When taken as directed, the naltrexone remains sequestered and patients receive oxycodone in an extended-release manner as intended.
If the pellets are crushed, the sequestered naltrexone is released and it counteracts the effects of oxycodone.
Abuse or misuse of Troxyca ER by cutting, breaking, chewing, crushing, or dissolving the pellets in Troxyca ER and then swallowing, snorting or injecting will result in the uncontrolled delivery of the oxycodone and can result in overdose and death.
Misuse or abuse of Troxyca ER may also release sufficient naltrexone to precipitate withdrawal in opioid-dependent individuals.
While Troxyca ER is designed to reduce abuse when crushed and administered by the oral and intranasal routes, abuse by these routes is still possible.
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What is low dose naltrexone (LDN)?
Low dose naltrexone means taking a dose of naltrexone that is up to one-tenth, or 10%, of the dose that is usually taken for opioid addiction. A low dose of naltrexone is approximately 4.5mg of naltrexone a day compared with the usual dosage of naltrexone for opioid addiction which is 50mg to 100mg a day. Continue reading
Can you take ibuprofen on an empty stomach?
Despite popular belief that you have to take ibuprofen with food, you can take ibuprofen on an empty stomach and this will give you faster pain relief than taking it with food. Food increases the time it takes for ibuprofen to be absorbed, although it won't affect how much is absorbed. There is actually no evidence that taking ibuprofen with food prevents gastric irritation – ibuprofen at OTC doses has a low incidence of gastric irritation anyway. Continue reading
Can you take expired ibuprofen?
Although taking expired ibuprofen is not recommended by the manufacturer, the actual shelf-life is likely to be longer than that indicated by the expiry date, with FDA testing showing many drugs are active for years beyond their expiry date, although specific data on ibuprofen is not available. Within reason, an ibuprofen tablet that is a few months past its expiry date is probably safe to take. Ibuprofen that is years past its expiry date should not be taken. Continue reading
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Drug information
- Troxyca ER Information for Consumers
- Troxyca ER prescribing info & package insert (for Health Professionals)
- Side Effects of Troxyca ER (detailed)
Related support groups
- Troxyca ER (1 questions, 3 members)
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