What is the difference between Tolsura and Sporanox?

Both Tolsura and Sporanox are capsules containing the azole antifungal itraconazole. Are they the same?

Tolsura and Sporanox are both capsules containing the azole antifungal itraconazole, however they are different strengths, they are formulated differently, and cannot be interchanged or substituted.

Tolsura is NOT indicated for the treatment of onychomycosis of the toenail and fingernail due to dermatophytes (tinea unguium), whereas Sporanox is indicated for onychomycosis.

Tolsura Capsules 65 mg

FDA Approved: 2018

Is a generic available? No

Tolsura is a patented formulation of itraconazole which incorporates proprietary SUBA technology (SUper-BioAvailable) developed to improve the bioavailability of poorly soluble drugs.

Tolsura is indicated for the treatment of the following fungal infections in immunocompromised and non-immunocompromised adult patients:

• Blastomycosis, pulmonary and extrapulmonary
• Histoplasmosis, including chronic cavitary pulmonary disease and disseminated, non-meningeal histoplasmosis, and
• Aspergillosis, pulmonary and extrapulmonary, in patients who are intolerant of or who are refractory to amphotericin B therapy.
• Tolsura is NOT indicated for the treatment of onychomycosis.

Tolsura capsules must be swallowed whole and taken with food to ensure maximum absorption.

Sporanox Capsules 100 mg

FDA Approved: 1992

Is a generic available? Yes

Sporanox was the first approved brand of itraconazole.

Sporanox is indicated for the treatment of the following fungal infections in immunocompromised and non-immunocompromised patients:

• Blastomycosis, pulmonary and extrapulmonary
• Histoplasmosis, including chronic cavitary pulmonary disease and disseminated, nonmeningeal histoplasmosis, and
• Aspergillosis, pulmonary and extrapulmonary, in patients who are intolerant of or who are refractory to amphotericin B therapy.
• Sporanox capsules are also indicated for the treatment of the following fungal infections in non-immunocompromised patients:
  • Onychomycosis of the toenail, with or without fingernail involvement, due to dermatophytes (tinea unguium), and
  • Onychomycosis of the fingernail due to dermatophytes (tinea unguium).

Sporanox capsules must be swallowed whole and taken with food to ensure maximum absorption.

See also:

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Drug information

• Itraconazole (53 reviews)
• Sporanox (18 reviews)
• Tolsura

Related support groups

• Itraconazole (8 questions, 15 members)
• Sporanox (4 questions, 7 members)
• Tolsura (1 questions, 3 members)
• Histoplasmosis (1 questions, 21 members)
• Aspergillosis (1 questions, 12 members)
• Blastomycosis (1 questions, 4 members)

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