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What is the difference between Symjepi and EpiPen?

Medically reviewed by Last updated on Oct 5, 2020.

Official Answer


EpiPen and Symjepi are both for intramuscular or subcutaneous use. However, unlike EpiPen, Symjepi is not labeled as an "autoinjector". The manufacturer reports that Symjepi will have a lower cost, smaller size and more user-friendly design than other products.

Like EpiPen, Symjepi (epinephrine) is a single-dose, prefilled syringe of epinephrine 0.3 mg used for emergency treatment of Type 1 allergic reactions such as insect stings, food allergies (like nuts or shellfish), or medications, among others.

Symjepi and EpiPen injectors are both designed for injection through clothing, but the manufacturer states that users of Symjepi should be in a seated position prior to injection in the thigh, while the EpiPen can be used while standing.

Symjepi, from Adamis, was FDA-approved in June 2017 and will be sold in a 2-pack like EpiPen. Auvi-Q from Kaleo, Adrenaclick from Impax, and generic alternatives are also available on the US market for emergency epinephrine delivery.

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