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Can I take Cymbalta (duloxetine) and Trintellix (vortioxetine) together?

Medically reviewed by Melisa Puckey, BPharm. Last updated on May 16, 2025.

Official Answer by Drugs.com

There is a major drug interaction between Cymbalta (duloxetine) and Trintellix (vortioxetine). Taking these medications together increases the risk of a rare condition called serotonin syndrome which is caused by an accumulation of too much serotonin.

Symptoms of serotonin syndrome include:

If you are taking these two medications together and have any of these symptoms you should seek immediate medical attention. Severe cases of serotonin syndrome may cause coma and even death.

What if I have been prescribed to take Cymbalta and Trintellix together?

Related questions

When can serotonin syndrome occur with Cymbalta and Trintellix?

Bottom line:

See also: Drug Interaction Checker

References

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