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What are the biosimilars of Herceptin?

Medically reviewed by Melisa Puckey, BPharm. Last updated on Aug 12, 2024.

Official Answer by Drugs.com

Herceptin (trastuzumab) is the original brand of trastuzumab, a biological medicine used to treat specific types of breast and gastric cancer, in specific patients and used in conjunction with prescribed treatment regimes.

What is the difference between generic and biosimilar medicines?

The biosimilars of Herceptin are:

Table comparing Herceptin to its Biosimilars

Brand name Herceptin Herzuma Kanjinti Ogivri Ontruzant Trazimera
Active ingredient name trastuzumab trastuzumab-pkrb trastuzumab-anns trastuzumab-dkst trastuzumab-dttb trastuzumab-qyyp
Company Genentech Celltrion Allergan
Amgen
Mylan Samsung Bioepis Pfizer
Approval date (FDA) 25 September 1998 14 December 2018 13 June 2019 1 December 2017 18 January 2019 11March 2019
Interchangeable? No No No No No No
Treatment* Adjuvant breast cancer,
Metastatic breast cancer,
Metastatic gastric cancer
Adjuvant breast cancer,
Metastatic breast cancer,
Metastatic gastric cancer
Adjuvant breast cancer,
Metastatic breast cancer,
Metastatic gastric cancer
Adjuvant breast cancer,
Metastatic breast cancer,
Metastatic gastric cancer
Adjuvant breast cancer,
Metastatic breast cancer,
Metastatic gastric cancer
Adjuvant breast cancer,
Metastatic breast cancer,
Metastatic gastric cancer
Form 150mg Single use vial,
420mg Multiple use vial
150mg Single use vial,
420mg Multiple use vial
150mg Single use vial,
420mg Multiple use vial
150mg Single use vial,
420mg Multiple use vial
150mg Single use vial,
420mg Multiple use vial
150mg Single use vial,
420mg Multiple use vial
Administration route intravenous infusion intravenous infusion intravenous infusion intravenous infusion intravenous infusion intravenous infusion

* Treatment is only indicated in these conditions for selected patients who have a specific type of cancer, who will be using specific treatment regimens, and patient selection can be dependent on previously used treatment options

Related questions

What is a biological medicine?

What is a reference product?

What does biosimilar mean?

What does ‘interchangeable product’ mean?

The biosimilars of Herceptin and NOT interchangeable.

References
  • Biosimilar and Interchangeable Products: https://www.fda.gov/drugs/biosimilars/biosimilar-and-interchangeable-products#generic
  • Herceptin Medication information: https://www.drugs.com/pro/herceptin.html

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