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Trazimera

Generic Name: trastuzumab (tras TOO zoo mab)
Brand Name: Herceptin, Herzuma, Kanjinti, Ogivri, Ontruzant, Trazimera

Medically reviewed by Drugs.com on Apr 29, 2020 – Written by Cerner Multum

What is Trazimera?

Trazimera is used to treat certain types of breast cancer or stomach cancer, sometimes in combination with other cancer medicines.

Trazimera is sometimes used when the cancer has spread to other parts of the body (metastatic).

Trazimera may also be used for purposes not listed in this medication guide.

Important Information

Do not use if you are pregnant. Use effective birth control, and tell your doctor if you become pregnant during treatment.

Trazimera can cause heart failure, especially if you have heart disease or if you are also receiving certain other cancer medicines.

Some side effects may occur during the injection. Tell your caregivers if you feel dizzy, nauseated, light-headed, weak, short of breath, or if you have a headache, fever, or chills.

Before taking this medicine

Tell your doctor if you have ever had:

Trazimera can cause heart failure, especially if you have heart disease or if you are also receiving certain other cancer medicines (such as daunorubicin, doxorubicin, epirubicin, or idarubicin).

You may need to have a negative pregnancy test before starting this treatment.

Do not use Trazimera if you are pregnant. Trazimera can cause injury or death to the unborn baby. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 7 months after your last dose. Tell your doctor if you become pregnant.

If you become pregnant while using Trazimera or within 7 months after you stop, your name may be listed on a pregnancy registry to track the effects of trastuzumab on the baby.

It may not be safe to breast-feed while using this medicine and for up to 7 months after your last dose. Ask your doctor about any risk.

How is Trazimera given?

Your doctor will perform a medical test to make sure Trazimera is the right medicine to treat your cancer.

Trazimera is given as an infusion into a vein. A healthcare provider will give you this injection.

Trazimera is usually given once every week or every 1 to 3 weeks. Follow your doctor's dosing instructions very carefully.

This medicine must be given slowly, and the infusion can take up to 90 minutes to complete.

You may need frequent medical tests to be sure this medicine is not causing harmful effects. Your cancer treatments may be delayed based on the results.

Your heart function may need to be checked before and during treatment with Trazimera. You may also need heart function testing every 6 months for 2 years after your last dose of this medicine.

Trazimera is usually given for 52 weeks, or until your body no longer responds to the medication.

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your Trazimera.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while receiving Trazimera?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Trazimera side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Some side effects may occur during the injection, or in the days afterward. Tell your caregiver right away if you feel dizzy, nauseated, itchy, light-headed, weak, short of breath, or if you have a headache, fever, chills, or chest pain.

Call your doctor at once if you have:

  • new or worsening cough, wheezing, chest tightness, or trouble breathing;

  • fever with shortness of breath or rapid breathing;

  • pounding heartbeats or fluttering in your chest;

  • a light-headed feeling, like you might pass out;

  • severe headache, blurred vision, pounding in your neck or ears;

  • blisters or ulcers in your mouth, red or swollen gums, trouble swallowing;

  • heart problems--swelling, rapid weight gain, feeling short of breath;

  • low blood cell counts--fever, chills, tiredness, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed; or

  • signs of tumor cell breakdown--confusion, weakness, muscle cramps, nausea, vomiting, fast or slow heart rate, decreased urination, tingling in your hands and feet or around your mouth.

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

Common side effects may include:

  • heart problems;

  • nausea, diarrhea, weight loss;

  • headache;

  • trouble sleeping, feeling tired;

  • low blood cell counts;

  • rash;

  • fever, chills, cough, or other signs of infection;

  • blisters or ulcers in your mouth, red or swollen gums, trouble swallowing;

  • altered sense of taste; or

  • cold symptoms such as stuffy nose, sinus pain, sore throat.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Trazimera?

Other drugs may affect Trazimera, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Trazimera can have long lasting effects on your heart, especially if you receive other cancer medicines. For at least 7 months after your last dose of trastuzumab, tell any doctor who treats you that you have used Trazimera.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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