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What is tdm1 chemotherapy?

Medically reviewed by Carmen Pope, BPharm. Last updated on Sep 26, 2023.

Official answer


T-DM1 chemotherapy refers to treatment with Kadcyla, which is a targeted treatment that may be used to treat HER2-positive breast cancer in women who meet certain criteria. The chemical name for Kadcyla is T-DM1 (also called ado-trastuzumab emtansine) and it is a combination of two medicines: trastuzumab which is a targeted treatment and DM1 which is a cytotoxic agent (also known as mertansine). Trastuzumab targets HER2-expressing breast cancer cells and delivers DM1 directly to them.

Kadcyla belongs to the class of medicines known as antibody-drug conjugates or ADCs. It may also be called a conjugated monoclonal antibody. Trastuzumab is also available by itself as Herceptin.


Kadcyla Breast

  • Kadcyla for Breast Cancer. Cancer Connect.
  • Trastuzumab emtansine (Kadcyla) Cancer Now.
  • Research and Development of Highly Potent Antibody-Based Drug Conjugates and Fusion Proteins for Cancer Therapy Rong-guang Shao, Yong-su Zhen, in Recent Advances in Cancer Research and Therapy, 2012

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