Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- Dilex-G 200 (dyphylline / guaifenesin)
- probenecid
Interactions between your drugs
probenecid dyphylline
Applies to: probenecid, Dilex-G 200 (dyphylline / guaifenesin)
Probenecid may inhibit the renal elimination of dyphylline. Dyphylline concentrations and risk of toxicity may be significantly increased. The clinical significance is unknown, as data are based on single-dose studies. Theophylline pharmacokinetics do not appear to be affected by probenecid and may be considered as an alternative.
References (3)
- Acara M, Carr EA Jr, Terry EN (1987) "Probenecid inhibition of the renal excretion of dyphyllin in chicken, rat and man." J Pharm Pharmacol, 39, p. 526-30
- Nadai M, Apichartpichean R, Hasegawa T, Nabeshima T (1992) "Pharmacokinetics and the effect of probenecid on the renal excretion mechanism of diprophylline." J Pharm Sci, 81, p. 1024-7
- May DC, Jarboe CH (1983) "Effect of probenecid on dyphylline elimination." Clin Pharmacol Ther, 33, p. 822-5
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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