Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- dyphylline
- Raplon (rapacuronium)
Interactions between your drugs
dyphylline rapacuronium
Applies to: dyphylline, Raplon (rapacuronium)
MONITOR: Methylxanthines may antagonize the effects of neuromuscular blockers. The mechanism is unknown. In patients stabilized on aminophylline, resistance to pancuronium has been reported.
MANAGEMENT: The patient should be monitored for adequate neuromuscular blockade and the dosage adjusted, if necessary.
References (3)
- Daller JA, Erstad B, Rosado L, Otto C, Putnam CW (1991) "Aminophylline antagonizes the neuromuscular blockade of pancuronium but not vecuronium." Crit Care Med, 19, p. 983-5
- Doll DC, Rosenberg H (1979) "Antagonism of neuromuscular blockage by theophylline." Anesth Analg, 58, p. 139-40
- Azar I, Kumar D, Betcher AM (1982) "Resistance to pancuronium in an asthmatic patient treated with aminophylline and steroids." Can Anaesth Soc J, 29, p. 280-2
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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