Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- doxepin topical
- Letybo (letibotulinumtoxinA)
Interactions between your drugs
doxepin topical letibotulinumtoxinA
Applies to: doxepin topical, Letybo (letibotulinumtoxinA)
MONITOR: Use of anticholinergic drugs after administration of botulinum toxin may potentiate systemic anticholinergic effects such as dry mouth, blurred vision, and urinary disorders. Botulinum toxin inhibits the release of acetylcholine from peripheral cholinergic nerve endings, thus additive or synergistic anticholinergic effects may occur when these agents are used together.
MANAGEMENT: Patients should be advised that systemic anticholinergic side effects such as dry mouth, blurred vision, and urinary disorders may increase if agents with anticholinergic properties (e.g., sedating antihistamines; antispasmodics; neuroleptics; phenothiazines; skeletal muscle relaxants; tricyclic antidepressants; disopyramide) are used after administration of botulinum toxin.
References (8)
- "Product Information. Myobloc (rimabotulinumtoxinB)." Elan Pharmaceuticals
- "Product Information. Dysport (abobotulinumtoxinA)." Tercica Inc
- "Product Information. Botox (onabotulinumtoxinA)." Allergan Inc
- (2022) "Product Information. Xeomin (incobotulinumtoxinA)." Merz Pharmaceuticals
- (2022) "Product Information. Jeuveau (prabotulinumtoxinA)." Evolus, Inc.
- (2022) "Product Information. Daxxify (daxibotulinumtoxinA)." Revance Therapeutics, Inc., 1
- (2022) "Product Information. Letybo (letibotulinumtoxinA)." CROMA Australia Pty Ltd, 1
- (2024) "Product Information. Letybo (letibotulinumtoxinA)." Hugel Aesthetics
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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