Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- dirithromycin
- oxtriphylline
Interactions between your drugs
oxtriphylline dirithromycin
Applies to: oxtriphylline, dirithromycin
Dirithromycin appears to have little or no effect on theophylline levels. It may rarely increase the plasma clearance of theophylline and plasma theophylline concentrations may be reduced by up to 26%. It is unlikely that the interaction with dirithromycin is clinically significant enough to modify outcome or require treatment adjustments.
References (3)
- Upton RA (1991) "Pharmacokinetic interactions between theophylline and other medication (Part I)." Clin Pharmacokinet, 20, p. 66-80
- Bachmann K, Nunlee M, Martin M, et al. (1990) "Changes in the steady-state pharmacokinetics of theophylline during treatment with dirithromycin." J Clin Pharmacol, 30, p. 1001-5
- Bachmann K, Jauregui L, Sides G, Sullivan TJ (1993) "Steady-state pharmacokinetics of theophylline in COPD patients treated with dirithromycin." J Clin Pharmacol, 33, p. 861-5
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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