Drug Interaction Report

GENERALLY AVOID: Dimethyl sulfoxide (DMSO) may reduce serum concentrations of the active metabolite, sulindac sulfide, by inhibiting sulindac reductase. The therapeutic effect of sulindac may be reduced. In addition, concomitant use of these agents has been reported to cause peripheral neuropathy. The mechanism is unknown.

MANAGEMENT: It may be advisable to avoid this drug combination.

GENERALLY AVOID: The concurrent use of aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs) and ethanol may lead to gastrointestinal (GI) blood loss. The mechanism may be due to a combined local effect as well as inhibition of prostaglandins leading to decreased integrity of the GI lining.

MANAGEMENT: Patients should be counseled on this potential interaction and advised to refrain from alcohol consumption while taking aspirin or NSAIDs.