Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- Dexacort Phosphate in Respihaler (dexamethasone)
- rifabutin
Interactions between your drugs
dexAMETHasone rifabutin
Applies to: Dexacort Phosphate in Respihaler (dexamethasone), rifabutin
MONITOR: Rifampin may induce the hepatic metabolism of corticosteroids, possibly reducing their therapeutic effect. The elimination half-life of corticosteroids has been shown to be reduced by up to 45% when rifampin is coadministered. Theoretically, rifabutin could interact with corticosteroids in a similar manner.
MANAGEMENT: Patients should be monitored for altered corticosteroid effects. Dosage increases may be necessary. Two- to threefold increases in prednisolone dosage have been recommended.
References (7)
- Venkatesan K (1992) "Pharmacokinetic drug interactions with rifampicin." Clin Pharmacokinet, 22, p. 47-65
- Bergrem H, Refvem OK (1983) "Altered prednisolone pharmacokinetics in patients treated with rifampicin." Acta Med Scand, 213, p. 339-43
- Powell-Jackson PR, Gray BJ, Heaton RW, et al. (1983) "Adverse effect of rifampicin administration on steroid-dependent asthma." Am Rev Respir Dis, 128, p. 307-10
- Kyriazopoulou V, Parparousi O, Vagenakis AG (1984) "Rifampicin-induced adrenal crisis in Addisonian patients receiving corticosteroid replacement therapy." J Clin Endocrinol Metab, 59, p. 1204-6
- McAllister WA, Thompson PJ, Al-Habet SM, Rogers HJ (1983) "Rifampicin reduces effectiveness and bioavailability of prednisolone." Br Med J, 286, p. 923-5
- Lee KH, Shin JG, Chong WS, Kim S, Lee JS, Jang IJ, Shin SG (1993) "Time course of the changes in prednisolone pharmacokinetics after co-administration or discontinuation of rifampin." Eur J Clin Pharmacol, 45, p. 287-9
- Strayhorn VA, Baciewicz AM, Self TH (1997) "Update on rifampin drug interactions, III." Arch Intern Med, 157, p. 2453-8
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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