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Drug Interaction Report

6 potential interactions and/or warnings found for the following 2 drugs:

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Interactions between your drugs

Moderate

ethinyl estradiol neratinib

Applies to: Cyred (desogestrel / ethinyl estradiol), neratinib

Neratinib may reduce the blood levels and effectiveness of ethinyl estradiol, which may make it less reliable as a form of birth control. Alternative or additional methods of birth control such as condoms should be used during treatment with neratinib and for up to 1 month after stopping treatment to avoid unintended pregnancy. Talk to your gynecologist or other healthcare professional for help in selecting an effective method of birth control that is best for you. If you take hormone replacement for menopause, you should contact your doctor if you experience increased frequency or worsening of your symptoms such as hot flashes, vaginal dryness, or abnormal bleeding. Men receiving neratinib should also use a condom during the treatment period and for 3 months after stopping treatment. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

desogestrel neratinib

Applies to: Cyred (desogestrel / ethinyl estradiol), neratinib

Neratinib may reduce the blood levels and effectiveness of desogestrel, which may make it less reliable as a form of birth control. Alternative or additional methods of birth control such as condoms should be used during treatment with neratinib and for up to 1 month after stopping treatment to avoid unintended pregnancy. Talk to your gynecologist or other healthcare professional for help in selecting an effective method of birth control that is best for you. If you take hormone replacement for menopause, you should contact your doctor if you experience increased frequency or worsening of your symptoms such as hot flashes, vaginal dryness, or abnormal bleeding. Men receiving neratinib should also use a condom during the treatment period and for 3 months after stopping treatment. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

Major

neratinib food

Applies to: neratinib

Grapefruit juice can increase the blood levels of neratinib. This may increase the risk and/or severity of side effects such as diarrhea, nausea, vomiting, abdominal pain, mouth sores, loss of appetite, and liver problems. You should avoid the consumption of grapefruit and grapefruit juice during treatment with neratinib. Be sure to take the medication with food at the same time everyday to maintain consistent blood levels and effects. Talk to your doctor or pharmacist if you have questions on how to take this or other medications you are prescribed. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

desogestrel food

Applies to: Cyred (desogestrel / ethinyl estradiol)

Grapefruit juice may increase the blood levels of certain medications such as desogestrel. You may want to limit your consumption of grapefruit and grapefruit juice during treatment with desogestrel. However, if you have been regularly consuming grapefruit or grapefruit juice with the medication, then it is advisable for you to talk with your doctor before changing the amounts of these products in your diet, as this may alter the effects of your medication. Contact your doctor if your condition changes or you experience increased side effects. Orange juice is not expected to interact.

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Minor

ethinyl estradiol food

Applies to: Cyred (desogestrel / ethinyl estradiol)

Information for this minor interaction is available on the professional version.

Minor

ethinyl estradiol food

Applies to: Cyred (desogestrel / ethinyl estradiol)

Information for this minor interaction is available on the professional version.

Therapeutic duplication warnings

No duplication warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.


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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

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Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.