Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- Cytosar (cytarabine)
- fludarabine
Interactions between your drugs
cytarabine fludarabine
Applies to: Cytosar (cytarabine), fludarabine
ADJUST DOSING INTERVAL: Cytarabine can impair the metabolism of fludarabine. The mechanism is inhibition of phosphorylation of arabinosyl-2-fluoroadenine. As a result, plasma levels of the active fludarabine triphosphate, F-ara-ATP, are decreased. Also, F-ara-ATP can potentiate deoxycytidine kinase--that is, the phosphorylation of cytarabine. As a result, plasma levels of the active cytarabine triphosphate, ara-CTP, are increased.
MANAGEMENT: It has been suggested that cytarabine be given as a relatively short-term infusion (two to four hours) following fludarabine to minimize metabolic interference with the subsequent fludarabine dose and to maximize ara-CTP synthesis.
References (2)
- Kemena A, Gandhi V, Shewach DS, Keating M, Plunkett W (1992) "Inhibition of fludarabine metabolism by arabinosylcytosine during therapy." Cancer Chemother Pharmacol, 31, p. 193-9
- Gandhi V, Estey E, Keating MJ, Plunkett W (1993) "Fludarabine potentiates metabolism of cytarabine in patients with acute myelogenous leukemia during therapy." J Clin Oncol, 11, p. 116-24
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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