Drug Interaction Report

CycloSPORINE can affect kidney function and may increase the blood levels of DAPTOmycin when used together. Contact your doctor if you experience increased side effects or your condition changes. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. You should seek immediate medical attention if you have unexplained muscle pain, tenderness or weakness, especially if accompanied by fever or dark colored urine, as these may be signs and symptoms of a serious medical condition known as rhabdomyolysis that can occasionally occur during treatment with DAPTOmycin. Rhabdomyolysis involves the breakdown of skeletal muscle tissue and, in some cases, can cause kidney damage and even death. Also let your doctor know if you experience other symptoms that could indicate more serious problems such as cough, breathlessness, fever, and burning, tingling, or numbness in the hands and feet. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Grapefruit and grapefruit juice can increase the levels of cycloSPORINE in your body and should generally not be consumed during treatment. High blood levels of cycloSPORINE can lead to increased risk of serious side effects on kidney, liver, and nervous system functions. If you regularly consume grapefruits or grapefruit juice, you should be monitored for side effects and/or changes in cycloSPORINE levels. However, do not increase or decrease the amount of grapefruit products in your diet without first talking to your doctor. You should also take cycloSPORINE on a consistent schedule with regard to time of day and relation to meals. Let your doctor know if you experience fever, rash, nausea, vomiting, abdominal pain, loss of appetite, dark urine, jaundice (yellowing of the skin or eyes), decreased urination, excessive thirst, swelling, weight gain, dizziness, fatigue, weakness, headache, blurred vision, numbness/burning/tingling in the hand and feet, tremors, or convulsions, as they may be symptoms caused by excessive effects of cycloSPORINE.