Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- conjugated estrogens topical
- Orilissa (elagolix)
Interactions between your drugs
conjugated estrogens topical elagolix
Applies to: conjugated estrogens topical, Orilissa (elagolix)
GENERALLY AVOID: Since endometriosis is fueled by estrogen, coadministration with estrogen-containing medications including combination oral contraceptive pills is expected to reduce the efficacy of elagolix. The effect of progestin-only contraceptives is unknown. Elagolix is a gonadotropin-releasing hormone (GnRH) receptor antagonist that inhibits endogenous GnRH signaling by binding competitively to GnRH receptors in the pituitary gland. Administration of elagolix results in dose-dependent suppression of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), leading to decreased levels of the ovarian sex hormones, estradiol and progesterone.
MANAGEMENT: Women requiring contraception should be advised to use non-hormonal forms of contraception during treatment with elagolix and for one week after its discontinuation.
References (1)
- (2018) "Product Information. Orilissa (elagolix)." AbbVie US LLC
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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