Drug Interaction Report
4 potential interactions and/or warnings found for the following 2 drugs:
- Equaline Acid Reducer (cimetidine)
- macitentan
Interactions between your drugs
cimetidine macitentan
Applies to: Equaline Acid Reducer (cimetidine), macitentan
Talk to your doctor before using macitentan together with cimetidine. Cimetidine may increase the blood levels of macitentan. In some cases, this may increase the risk and/or severity of side effects such as headache, anemia and liver problems, especially during prolonged treatment. Your doctor may be able to prescribe alternatives that do not interact. Call your doctor immediately if you have fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark colored urine, light colored stools, and/or yellowing of the skin or eyes, as these may be signs and symptoms of liver damage. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Drug and food interactions
cimetidine food
Applies to: Equaline Acid Reducer (cimetidine)
Information for this minor interaction is available on the professional version.
cimetidine food
Applies to: Equaline Acid Reducer (cimetidine)
Information for this minor interaction is available on the professional version.
cimetidine food
Applies to: Equaline Acid Reducer (cimetidine)
Information for this minor interaction is available on the professional version.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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