Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- Chloromycetin Sodium Succinate (chloramphenicol)
- lincomycin
Interactions between your drugs
chloramphenicol lincomycin
Applies to: Chloromycetin Sodium Succinate (chloramphenicol), lincomycin
MONITOR: Chloramphenicol, erythromycin, lincomycin, and/or clindamycin may antagonize each other's bactericidal effects if used concomitantly. Lincomycin derivatives, erythromycin and chloramphenicol have antagonistic effects in vitro. The mechanism is competitive binding of the 50S ribosomal subunit.
MANAGEMENT: Until more data are available, the possibility of antagonism should be considered, and patients should be monitored for altered therapeutic effect of either antibiotic.
References (7)
- (2002) "Product Information. Cleocin (clindamycin)." Pharmacia and Upjohn
- Limbird LE eds., Gilman AG, Hardman JG (1995) "Goodman and Gilman's the Pharmacological Basis of Therapeutics." New York, NY: McGraw-Hill
- (2015) "Product Information. Chloromycetin Succinate (chloramphenicol)." Link Medical Products Pty Ltd T/A Link Pharmaceuticals
- (2024) "Product Information. Clindamycin (clindamycin)." Rivopharm (UK) Ltd
- (2023) "Product Information. Eryc (ERYthromycin)." Mayne Pharma International Pty Ltd
- (2024) "Product Information. Erythrocin (erythromycin)." Advanz Pharma
- (2024) "Product Information. Clindamycin (Apo) (clindamycin)." Apotex Pty Ltd
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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