Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- carvedilol
- Zegalogue (dasiglucagon)
Interactions between your drugs
carvedilol dasiglucagon
Applies to: carvedilol, Zegalogue (dasiglucagon)
Beta-blockers may blunt the hyperglycemic reaction to glucagon by interfering with beta-adrenergic-mediated hyperglycemic counter-regulatory mechanisms. In addition, glucagon may diminish the bradycardic effect of beta-blockers by inducing a transient increase in pulse and blood pressure. Patients with coronary artery disease may require treatment for the potential increase in blood pressure and heart rate.
References (11)
- Pun KK, Yeung CK, Chak W, et al. (1986) "Effects of selective and non-selective beta-blockers on the alanine and free fatty acid responses to glucagon challenge in hemodialysis patients." Clin Nephrol, 26, p. 222-6
- Messerli FH, Kuchel O, Tolis G, Hamet P, Fraysse J, Genest J (1976) "Effects of B-adrenergic blockade on plasma cyclic AMP and blood sugar responses to glucagon and isoproterenol in man." Int J Clin Pharmacol, 14, p. 189-94
- Smith RC, Wilkinson DO, Hull RL (1985) "Glucagon for propranolol overdose." JAMA, 254, p. 2412
- Mills GA, Horn JR (1985) "B-blockers and glucose control." Drug Intell Clin Pharm, 19, p. 246-51
- Smith RC, Wilkinson J, Hull RL (1985) "Glucagon for propranolol overdose." JAMA, 254, p. 2412
- (2001) "Product Information. Glucagon (glucagon)." Lilly, Eli and Company
- (2001) "Product Information. GlucaGen (glucagon)." Novo Nordisk Pharmaceuticals Inc
- Cerner Multum, Inc. "UK Summary of Product Characteristics."
- Cerner Multum, Inc. "Australian Product Information."
- (2019) "Product Information. Baqsimi (glucagon)." Lilly, Eli and Company
- (2021) "Product Information. Zegalogue Prefilled Syringe (dasiglucagon)." Zealand Pharma A/S
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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