Drug Interaction Report

Consumer information for this interaction is not currently available.

ADJUST DOSE: Coadministration with moderate inducers of CYP450 3A4 may decrease the plasma concentrations of crinecerfont, which is primarily metabolized by the isoenzyme. Concomitant use with rifampin, a potent CYP450 3A4 inducer, decreased crinecerfont peak plasma concentration (Cmax) and systemic exposure (AUC) by 23% and 62%, respectively. No data are available for other, less potent inducers. Reduced efficacy of crinecerfont may occur.

MANAGEMENT: When coadministered with moderate CYP450 3A4 inducers, the crinecerfont evening dose should be increased.
In adults, increase the crinecerfont dose to 200 mg with a meal in the evening (morning dose of 100 mg with a meal remains unchanged).

In pediatric patients 4 years of age and older, increase the crinecerfont dose based on weight:
-Patients weighing 10 kg to less than 20 kg: 50 mg with a meal in the evening (morning dose of 25 mg with a meal remains unchanged)
-Patients weighing 20 kg to less than 55 kg: 100 mg with a meal in the evening (morning dose of 50 mg with a meal remains unchanged)
-Patients weighing 55 kg or more: 200 mg with a meal in the evening (morning dose of 100 mg with a meal remains unchanged)

Consumer information for this interaction is not currently available.

ADJUST DOSING INTERVAL: Coadministration with food increases the oral bioavailability of crinecerfont. Administration of crinecerfont capsules and oral solution with a high-fat meal (800 to 1000 calories, 50% fat), increased crinecerfont peak plasma concentration (Cmax) by 4.9-fold and 8.6-fold, respectively, and systemic exposure (AUC) by 3.3-fold and 8.3-fold, respectively, compared to administration under fasting conditions.

MANAGEMENT: Crinecerfont should be administered twice daily with a meal in the morning and evening without regard to fat or calorie content.

Both EPINEPHrine and caffeine can increase blood pressure and heart rate, and combining them may enhance these effects. Talk to your doctor before using these medications, especially if you have a history of high blood pressure or heart disease. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.