Drug Interaction Report
2 potential interactions and/or warnings found for the following 2 drugs:
- bupivacaine / dexamethasone / epinephrine
- iohexol
Interactions between your drugs
dexAMETHasone iohexol
Applies to: bupivacaine / dexamethasone / epinephrine, iohexol
CONTRAINDICATED: Coadministration of corticosteroids with iodinated contrast media by the intrathecal route may be associated with a high incidence of radiographic arachnoiditis. Meningitis and seizures may also occur.
MANAGEMENT: Intrathecal coadministration of corticosteroids with iodinated contrast media is considered contraindicated.
References (5)
- (2001) "Product Information. Amipaque (metrizamide)." Nycomed Inc
- (2001) "Product Information. Osmovist 240 (iotrolan)." Berlex Canada Inc
- (2007) "Product Information. Omnipaque 180 (iohexol)." Amersham Health
- (2007) "Product Information. Isovue-M-200 (iopamidol)." Bracco Diagnostics Inc
- Nelson DA, Landau WM (2001) "Intraspinal steroids: history, efficacy, accidentality, and controversy with review of United States Food and Drug Administration reports." J Neurol Neurosurg Psychiatry, 70, p. 433-43
Drug and food interactions
EPINEPHrine food
Applies to: bupivacaine / dexamethasone / epinephrine
MONITOR: Coadministration of two or more sympathomimetic agents may increase the risk of adverse effects such as nervousness, irritability, and increased heart rate. Central nervous system (CNS) stimulants, particularly amphetamines, can potentiate the adrenergic response to vasopressors and other sympathomimetic agents. Additive increases in blood pressure and heart rate may occur due to enhanced peripheral sympathetic activity.
MANAGEMENT: Caution is advised if two or more sympathomimetic agents are coadministered. Pulse and blood pressure should be closely monitored.
References (7)
- Rosenblatt JE, Lake CR, van Kammen DP, Ziegler MG, Bunney WE Jr (1979) "Interactions of amphetamine, pimozide, and lithium on plasma norepineophrine and dopamine-beta-hydroxylase in schizophrenic patients." Psychiatry Res, 1, p. 45-52
- Cavanaugh JH, Griffith JD, Oates JA (1970) "Effect of amphetamine on the pressor response to tyramine: formation of p-hydroxynorephedrine from amphetamine in man." Clin Pharmacol Ther, 11, p. 656
- (2001) "Product Information. Adderall (amphetamine-dextroamphetamine)." Shire Richwood Pharmaceutical Company Inc
- (2001) "Product Information. Tenuate (diethylpropion)." Aventis Pharmaceuticals
- (2001) "Product Information. Sanorex (mazindol)." Novartis Pharmaceuticals
- (2001) "Product Information. Focalin (dexmethylphenidate)." Mikart Inc
- (2002) "Product Information. Strattera (atomoxetine)." Lilly, Eli and Company
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
Report options
- Switch to consumer interaction data
- Email this report to a friend, doctor, or patient
- Ask questions, find answers
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
See also:
Diprivan
Diprivan is an intravenous sedative used for general anesthesia and to sedate patients on ...
Levsin
Levsin is used to treat stomach problems such as cramps and irritable bowel syndrome and conditions ...
Ozempic
Learn about Ozempic (semaglutide) for type 2 diabetes treatment, weight management, cardiovascular ...
Stadol
Stadol is used for anesthesia, anesthetic adjunct, labor pain, pain
Duragesic
Duragesic skin patch is used to treat moderate to severe chronic pain. Learn about side effects ...
Emla
Emla (lidocaine and prilocaine) is a cream used to numb the skin in preparation for medical ...
Hyosyne
Hyosyne is used for anticholinesterase poisoning, diverticulitis, irritable bowel syndrome ...
Learn more
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Check Interactions
To view an interaction report containing 4 (or more) medications, please sign in or create an account.
Save Interactions List
Sign in to your account to save this drug interaction list.