Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- ceftobiprole medocaril
- Demadex IV (torsemide)
Interactions between your drugs
torsemide ceftobiprole
Applies to: Demadex IV (torsemide), ceftobiprole medocaril
Consumer information for this interaction is not currently available.
MONITOR: Limited data suggest that furosemide and possibly other loop diuretics may potentiate the nephrotoxicity of some cephalosporins. The exact mechanism of interaction is unknown, although furosemide has been shown to increase the plasma concentrations and/or reduce the clearance of several cephalosporins such as cephaloridine and ceftazidime. Data from an early study identified an association between diuretic use and acute renal failure during cephaloridine treatment. Specifically, 9 out of 36 patients who developed acute renal failure while on cephaloridine were also receiving a diuretic (primarily furosemide). Other risk factors included shock, infection, excessive dosage of cephaloridine, and concomitant use of other potentially nephrotoxic drugs. Several case reports have also suggested an increased risk of nephrotoxicity with the combination of furosemide and cephaloridine or cephalothin, and one study found that administration of furosemide or ethacrynic acid increased both the incidence and extent of proximal renal tubular necrosis in cephaloridine-treated mice and rats. In contrast, a study conducted in patients with preexisting moderate renal impairment found no effect of furosemide on the serum half-life of cefoxitin, and glomerular filtration rate was not affected during concomitant administration of cefoxitin and furosemide.
MANAGEMENT: Although data are primarily limited to cephaloridine, which is no longer commercially marketed, caution may be advisable in patients receiving a loop diuretic in combination with other cephalosporins. Renal function should be monitored, particularly when high dosages are used or when these medications are administered in the elderly or patients with preexisting renal impairment.
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
See also:
Augmentin
Augmentin is a prescription antibiotic combining amoxicillin and clavulanate to treat bacterial ...
Bactrim
Bactrim (sulfamethoxazole and trimethoprim) is an antibiotic used to treat ear infections, urinary ...
Ozempic
Learn about Ozempic (semaglutide) for type 2 diabetes treatment, weight management, cardiovascular ...
Keflex
Keflex (cephalexin) is used to treat infections caused by bacteria, including respiratory ...
Cipro
Cipro (ciprofloxacin) is a fluoroquinolone antibiotic used to treat bacterial infections. Learn ...
Zithromax
Zithromax (azithromycin) treats infections caused by bacteria, such as respiratory infections, skin ...
Flagyl
Flagyl is used to treat bacterial infections of the vagina, stomach, skin and joints. Learn about ...
Levaquin
Levaquin (levofloxacin) is used to treat bronchitis, pneumonia, chlamydia, gonorrhea and skin ...
Rocephin
Rocephin (ceftriaxone) is used to treat bacterial infections, including severe or life-threatening ...
Azithromycin Dose Pack
Azithromycin Dose Pack is used for babesiosis, bacterial endocarditis prevention, bacterial ...
Learn more
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Check Interactions
To view an interaction report containing 4 (or more) medications, please sign in or create an account.
Save Interactions List
Sign in to your account to save this drug interaction list.