Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- dapsone / niacinamide / tretinoin topical
- trimetrexate
Interactions between your drugs
trimetrexate dapsone topical
Applies to: trimetrexate, dapsone / niacinamide / tretinoin topical
Folate antagonists have been reported to possibly increase the likelihood of hematologic reactions (e.g., agranulocytosis, anemia) associated with oral dapsone. The effect on topically administered dapsone is unknown. Exposure to dapsone from the recommended topical dose for acne vulgaris is about 1% of that from a 100 mg oral dose.
References (1)
- (2005) "Product Information. Aczone (dapsone topical)." QLT USA, Inc
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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