Drug Interaction Report

Posaconazole may increase the blood levels and effects of mirvetuximab soravtansine. This may increase the risk of serious side effects such as blurred vision, dry eyes, sensitivity to light, eye pain, or new or worsening vision changes, severe or life-threatening inflammation of the lungs, and nerve problems called peripheral neuropathy. Contact your doctor immediately if you develop eye problems, trouble breathing, shortness of breath, cough, or chest pain, new or worsening numbness or tingling in your hands or feet or muscle weakness during treatment. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Food significantly increases the absorption of posaconazole from the tablet or suspension formulations. The manufacturer recommends that you take the tablet with food and the oral suspension during or immediately (within 20 minutes) after a full meal. If you cannot eat a full meal, you should take the oral suspension with a liquid nutritional supplement like Ensure or an acidic carbonated beverage like ginger ale. Do not take these medications on an empty stomach, as it may lead to inadequate blood levels and reduced effectiveness. Ask your doctor before using alcohol together with posaconazole from delayed release suspension formulations as this may cause an increase in side effects. Talk to your doctor or pharmacist if you have any questions on how to use the medication properly.