Drug Interaction Report
2 potential interactions and/or warnings found for the following 2 drugs:
- lactitol
- Onivyde (irinotecan liposomal)
Interactions between your drugs
lactitol irinotecan liposomal
Applies to: lactitol, Onivyde (irinotecan liposomal)
GENERALLY AVOID: Because irinotecan has been reported to cause diarrhea in the majority of treated patients, the use of laxatives may not be appropriate during irinotecan therapy.
MANAGEMENT: In patients requiring laxatives for constipation associated with narcotic administration, the standard regimen may be continued under supervision of the clinician. However, patients should be advised to inform their physician of any changes in their bowel habit so that dosage adjustments or discontinuation of laxatives may be done promptly.
References (1)
- (2001) "Product Information. Camptosar (irinotecan)." Pharmacia and Upjohn
Drug and food interactions
lactitol food
Applies to: lactitol
ADJUST DOSING INTERVAL: Lactitol may decrease the absorption of concomitantly administered oral medications.
MANAGEMENT: Lactitol should be administered at least 2 hours before or 2 hours after concomitant oral medications.
References (1)
- (2020) "Product Information. Pizensy (lactitol)." Braintree Laboratories
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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