Drug Interaction Report
2 potential interactions and/or warnings found for the following 2 drugs:
- lactitol
- Linzess (linaclotide)
Interactions between your drugs
No drug ⬌ drug interactions were found between the drugs in your list. However, this does not necessarily mean no drug interactions exist. Always consult your healthcare provider.
Drug and food interactions
lactitol food
Applies to: lactitol
ADJUST DOSING INTERVAL: Lactitol may decrease the absorption of concomitantly administered oral medications.
MANAGEMENT: Lactitol should be administered at least 2 hours before or 2 hours after concomitant oral medications.
References (1)
- (2020) "Product Information. Pizensy (lactitol)." Braintree Laboratories
linaclotide food
Applies to: Linzess (linaclotide)
ADJUST DOSING INTERVAL: Administration of linaclotide in the fed condition resulted in more gastrointestinal side effects and more frequent and looser stools, than when it was administered under fasting conditions.
MANAGEMENT: It is recommended to take linaclotide 30 minutes before a meal.
References (2)
- EMEA. European Medicines Agency (2007) EPARs. European Union Public Assessment Reports. http://www.ema.europa.eu/ema/index.jsp?curl=pages/includes/medicines/medicines_landingpage.jsp&mid
- (2012) "Product Information. Linzess (linaclotide)." Forest Pharmaceuticals
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Linzess
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Trulance
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Motegrity
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Plecanatide
Plecanatide is used for chronic idiopathic constipation, constipation, irritable bowel syndrome ...
Prucalopride
Prucalopride is used for chronic idiopathic constipation, constipation
Linaclotide
Linaclotide is used for chronic idiopathic constipation, constipation, functional constipation ...
Lubiprostone
Lubiprostone is used for chronic idiopathic constipation, constipation, irritable bowel syndrome ...
Learn more
Further information
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