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Drug Interaction Report

3 potential interactions and/or warnings found for the following 2 drugs:

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Interactions between your drugs

Moderate

nafcillin omadacycline

Applies to: Unipen (nafcillin), omadacycline

Consumer information for this interaction is not currently available.

GENERALLY AVOID: Tetracyclines may reduce the effect of penicillins by inhibiting cellular protein synthesis which is necessary for cell wall synthesis inhibition by penicillins. Antagonism is more likely when low doses of either agent are administered. Therapeutic failure may result.

MANAGEMENT: This combination should be avoided if possible.

Drug and food interactions

Moderate

nafcillin food

Applies to: Unipen (nafcillin)

You may experience reduced absorption of nafcillin in the presence of food. The effectiveness of the antibiotic may be reduced. Nafcillin should be administered one hour before or two hours after meals. This will make it easier for your body to absorb the medication. Penicillin V and amoxicillin are not affected by food and may be given without regard to meals.

Moderate

omadacycline food

Applies to: omadacycline

Do not take iron supplements, multivitamins, calcium supplements, or antacids within 4 hours before or after taking omadacycline. These products can make omadacycline less effective in treating your infection. Omadacycline should be taken at least 2 hours before (4 hours for dairy products) or 4 hours after meals. Dairy products can make it harder for your body to absorb the medication.

Therapeutic duplication warnings

No duplication warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

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Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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