Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- Arikayce (amikacin liposome)
- clarithromycin
Interactions between your drugs
No drug ⬌ drug interactions were found between the drugs in your list. However, this does not necessarily mean no drug interactions exist. Always consult your healthcare provider.
Drug and food interactions
clarithromycin food
Applies to: clarithromycin
Grapefruit juice may delay the gastrointestinal absorption of clarithromycin but does not appear to affect the overall extent of absorption or inhibit the metabolism of clarithromycin. The mechanism of interaction is unknown but may be related to competition for intestinal CYP450 3A4 and/or absorptive sites. In an open-label, randomized, crossover study consisting of 12 healthy subjects, coadministration with grapefruit juice increased the time to reach peak plasma concentration (Tmax) of both clarithromycin and 14-hydroxyclarithromycin (the active metabolite) by 80% and 104%, respectively, compared to water. Other pharmacokinetic parameters were not significantly altered. This interaction is unlikely to be of clinical significance.
References (1)
- Cheng KL, Nafziger AN, Peloquin CA, Amsden GW (1998) "Effect of grapefruit juice on clarithromycin pharmacokinetics." Antimicrob Agents Chemother, 42, p. 927-9
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
Report options
- Switch to consumer interaction data
- Email this report to a friend, doctor, or patient
- Ask questions, find answers
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
See also:
Cipro
Cipro (ciprofloxacin) is a fluoroquinolone antibiotic used to treat bacterial infections. Learn ...
Zithromax
Zithromax (azithromycin) treats infections caused by bacteria, such as respiratory infections, skin ...
Botox
Botox is used for cosmetic purposes and to treat overactive bladder symptoms, urinary incontinence ...
Azithromycin Dose Pack
Azithromycin Dose Pack is used for babesiosis, bacterial endocarditis prevention, bacterial ...
Biaxin
Biaxin is used for bacterial endocarditis prevention, bronchitis, dental abscess, helicobacter ...
Biaxin XL
Biaxin XL (clarithromycin) is used to treat bacterial infections affecting the skin and respiratory ...
Streptomycin
Streptomycin is used for brucellosis, endocarditis, mycobacterium avium-intracellulare, treatment ...
Ethambutol
Ethambutol is used for mycobacterium avium-intracellulare, prophylaxis, mycobacterium ...
Ofloxacin
Ofloxacin is used for anthrax, anthrax prophylaxis, bladder infection, bone infection, bronchitis ...
Clarithromycin
Clarithromycin is used to treat bacterial infections affecting the skin and respiratory system ...
Learn more
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Check Interactions
To view an interaction report containing 4 (or more) medications, please sign in or create an account.
Save Interactions List
Sign in to your account to save this drug interaction list.