Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- Bismarex (bismuth subsalicylate)
- levamlodipine
Interactions between your drugs
bismuth subsalicylate levamlodipine
Applies to: Bismarex (bismuth subsalicylate), levamlodipine
MONITOR: Limited data indicate that some cyclooxygenase inhibitors may attenuate the antihypertensive effects of some calcium channel blockers. The mechanism appears to be related to an alteration of vascular tone, which is dependent on prostacyclins and other vasodilatory prostanoids. When a nonsteroidal anti-inflammatory drug (NSAID) is added to the regimen of a patient who is already taking a calcium channel blocker, increased blood pressure may result. Also, the clinician should be aware that the risk of hypotension is increased when NSAIDs are withdrawn from the regimen.
MANAGEMENT: Monitoring for altered blood pressure control is recommended.
References (9)
- Ring ME, Corrigan JJ, Fenster PE (1986) "Effects of oral diltiazem on platelet function: alone and in combination with "low dose" aspirin." Thromb Res, 44, p. 391-400
- Altman R, Scazziota A, Dujovne C (1988) "Diltiazem potentiates the inhibitory effect of aspirin on platelet aggregation." Clin Pharmacol Ther, 44, p. 320-5
- Cremer KF, Pieper JA, Joyal M, Mehta J (1984) "Effects of diltiazem, dipyridamole, and their combination on hemostasis." Clin Pharmacol Ther, 36, p. 641-4
- Minuz P, Pancera P, Ribul M, et al. (1995) "Amlodipine and haemodynamic effects of cyclo-oxygenase inhibition." Br J Clin Pharmacol, 39, p. 45-50
- Houston MC, Weir M, Gray J, et al. (1995) "The effects of nonsteroidal anti-inflammatory drugs on blood pressures of patients with hypertension controlled by verapamil." Arch Intern Med, 155, p. 1049-54
- Deleeuw PW (1996) "Nonsteroidal anti-inflammatory drugs and hypertension: the risks in perspective." Drugs, 51, p. 179-87
- "Product Information. DurAct (bromfenac)." Wyeth-Ayerst Laboratories
- (2001) "Product Information. Arthrotec (diclofenac-misoprostol)." Searle
- Zanchetti A, Hansson L, Leonetti G, et al. (2002) "Low-dose aspirin does not interfere with the blood pressure-lowering effects of antihypertensive therapy." J Hypertens, 20, p. 1015-1022
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
Report options
- Switch to consumer interaction data
- Email this report to a friend, doctor, or patient
- Ask questions, find answers
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
See also:
Protonix
Protonix (pantoprazole) is used to treat erosive esophagitis and other conditions involving excess ...
Bactrim
Bactrim (sulfamethoxazole and trimethoprim) is an antibiotic used to treat ear infections, urinary ...
Botox
Botox is used for cosmetic purposes and to treat overactive bladder symptoms, urinary incontinence ...
Nexium
Nexium is used to treat GERD and other conditions involving excessive stomach acid. Learn about ...
Pepcid
Pepcid is used to treat ulcers in the stomach and for conditions where the stomach produces too ...
Cipro
Cipro (ciprofloxacin) is a fluoroquinolone antibiotic used to treat bacterial infections. Learn ...
Prilosec
Prilosec (omeprazole) is used to treat symptoms of GERD and other conditions caused by excess ...
Flagyl
Flagyl is used to treat bacterial infections of the vagina, stomach, skin and joints. Learn about ...
Xifaxan
Xifaxan (rifaximin) is used to treat travelers' diarrhea, irritable bowel syndrome with diarrhea ...
Learn more
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Check Interactions
To view an interaction report containing 4 (or more) medications, please sign in or create an account.
Save Interactions List
Sign in to your account to save this drug interaction list.