Drug Interaction Report

GENERALLY AVOID: Coadministration with potent inducers of CYP450 1A2, CYP450 3A4, and/or P-glycoprotein may decrease the plasma concentrations of pomalidomide, which has been shown to be primarily metabolized by these isoenzymes and also a substrate of the efflux transporter.

MANAGEMENT: Concomitant use of pomalidomide with potent inducers of CYP450 isoenzymes and/or P-glycoprotein should generally be avoided.

MONITOR: Cigarette smoking may reduce pomalidomide exposure due to induction of CYP450 1A2, the isoenzyme that is responsible for the metabolic clearance of pomalidomide along with CYP450 3A4.

MANAGEMENT: Patients should be advised that smoking may reduce the efficacy of pomalidomide therapy. Pomalidomide should be taken on an empty stomach, at least 2 hours before or 2 hours after a meal.