Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- apalutamide
- daclatasvir
Interactions between your drugs
daclatasvir apalutamide
Applies to: daclatasvir, apalutamide
CONTRAINDICATED: Coadministration with potent inducers of CYP450 3A4 may significantly decrease the plasma concentration of daclatasvir, which is primarily metabolized by the isoenzyme. When a single 60 mg dose of daclatasvir was administered following pretreatment with the potent CYP450 3A4 inducer rifampin (600 mg once daily), daclatasvir peak plasma concentration (Cmax) and systemic exposure (AUC) decreased by 56% and 79%, respectively. Loss of therapeutic efficacy may occur.
MANAGEMENT: Given the risk of reduced viral susceptibility and resistance development associated with subtherapeutic antiviral drug levels, concomitant use of daclatasvir with potent CYP450 3A4 inducers is considered contraindicated.
References (2)
- Cerner Multum, Inc. "UK Summary of Product Characteristics."
- (2015) "Product Information. Daklinza (daclatasvir)." Bristol-Myers Squibb
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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