Drug Interaction Report

Consumer information for this interaction is not currently available.

MONITOR: Coadministration with inducers of CYP450 3A4 may decrease the plasma concentrations of saxagliptin, which is primarily metabolized by the isoenzyme. According to the product labeling, administration of a single 5 mg dose of saxagliptin in combination with the potent CYP450 3A4 inducer rifampin (600 mg once daily at steady state) resulted in decreases to saxagliptin peak plasma concentration (Cmax) by 53% and systemic exposure (AUC) by 76%. These changes were accompanied by a 39% increase in Cmax but no significant change in the AUC of the pharmacologically active metabolite, 5-hydroxysaxagliptin. Overall, the plasma dipeptidyl peptidase-4 (DPP4) inhibition activity of saxagliptin over a 24-hour dose interval was not affected by rifampin.

MANAGEMENT: Dosage adjustment of saxagliptin is not necessary during coadministration with rifampin or other CYP450 3A4 inducers. However, glycemic control should be closely monitored, and the physician notified if an interaction is suspected.

Alcohol may affect blood glucose levels in patients with diabetes. Both hypoglycemia (low blood sugar) and hyperglycemia (high blood sugar) may occur, depending on how much and how often you drink. You should avoid using alcohol if your diabetes is not well controlled or if you have high triglycerides, neuropathy (nerve damage), or pancreatitis. Moderate alcohol consumption generally does not affect blood glucose levels if your diabetes is under control. However, it may be best to limit alcohol intake to one drink daily for women and two drinks daily for men (1 drink = 5 oz wine, 12 oz beer, or 1.5 oz distilled spirits) in conjunction with your normal meal plan. Avoid drinking alcohol on an empty stomach or following exercise, as it may increase the risk of hypoglycemia. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.