Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- enzalutamide
- Livtencity (maribavir)
Interactions between your drugs
enzalutamide maribavir
Applies to: enzalutamide, Livtencity (maribavir)
GENERALLY AVOID: Coadministration with potent inducers of CYP450 3A4 may significantly decrease the plasma concentrations of maribavir, which is primarily metabolized by the isoenzyme. When maribavir (400 mg twice daily) was administered with the potent CYP450 3A4 inducer, rifampin (600 mg once daily), maribavir peak plasma concentration (Cmax) and systemic exposure (AUC) decreased by 39% and 60%, respectively. Reduced virologic response to maribavir may occur.
MANAGEMENT: Concomitant use of maribavir with potent CYP450 3A4 inducers is not recommended.
References (1)
- (2021) "Product Information. Livtencity (maribavir)." Takeda Pharmaceuticals America
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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