Drug Interaction Report
2 potential interactions and/or warnings found for the following 2 drugs:
- ulipristal
- zafirlukast
Interactions between your drugs
zafirlukast ulipristal
Applies to: zafirlukast, ulipristal
Coadministration with CYP450 3A4 inhibitors may increase the plasma concentrations of ulipristal, which is primarily metabolized by the isoenzyme. The clinical relevance is unknown.
References (2)
- Cerner Multum, Inc. "UK Summary of Product Characteristics."
- (2022) "Product Information. Ella (ulipristal)." Afaxys Inc.
Drug and food/lifestyle interactions
zafirlukast food/lifestyle
Applies to: zafirlukast
ADJUST DOSING INTERVAL: Food may reduce the oral absorption and bioavailability of zafirlukast. In two separate studies, one using a high-fat and the other a high-protein meal, administration of zafirlukast with food reduced the mean bioavailability by approximately 40%.
MANAGEMENT: To ensure maximal oral absorption, zafirlukast should be administered at least 1 hour before or 2 hours after meals.
References (1)
- (2001) "Product Information. Accolate (zafirlukast)." Astra-Zeneca Pharmaceuticals
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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