Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- Penicillin G Procaine (procaine penicillin)
- tigecycline
Interactions between your drugs
tigecycline procaine penicillin
Applies to: tigecycline, Penicillin G Procaine (procaine penicillin)
GENERALLY AVOID: Tetracyclines may reduce the effect of penicillins by inhibiting cellular protein synthesis which is necessary for cell wall synthesis inhibition by penicillins. Antagonism is more likely when low doses of either agent are administered. Therapeutic failure may result.
MANAGEMENT: This combination should be avoided if possible.
References (6)
- Gunnison JB, Coleman VR, Jawetz E (1950) "Interference of aureomycin and of terramycin with action of penicillin in vitro." Proc Soc Exp Biol Med, 75, p. 549-52
- Lepper MH, Dowling HF (1951) "Treatment of pneumococcic meningitis with penicillin compared with penicillin plus aureomycin." Arch Intern Med, 88, p. 489-94
- Jawetz E (1975) "Synergism and antagonism among antimicrobial drugs: a personal perspective." West J Med, 123, p. 87-91
- Olsson RA, Kirby JC, Romansky MJ (1961) "Pneumococcal meningitis in the adult." Ann Intern Med, 55, p. 545-9
- (2001) "Product Information. Declomycin (demeclocycline)." Lederle Laboratories
- (2018) "Product Information. Seysara (sarecycline)." Allergan Inc
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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