Drug Interaction Report
3 potential interactions and/or warnings found for the following 2 drugs:
- methylnaltrexone
- Triumeq (abacavir / dolutegravir / lamivudine)
Interactions between your drugs
methylnaltrexone dolutegravir
Applies to: methylnaltrexone, Triumeq (abacavir / dolutegravir / lamivudine)
Dolutegravir may increase the blood levels and effects of methylnaltrexone. You may need a dose adjustment if you have been receiving methylnaltrexone and are starting treatment with dolutegravir. Likewise, if you have been receiving both medications, the dose of methylnaltrexone may need to be adjusted if dolutegravir is discontinued. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Drug and food interactions
methylnaltrexone food
Applies to: methylnaltrexone
Food may reduce the absorption of methylnaltrexone when taken orally, which may lead to lower blood levels of the medication and possibly reduced effectiveness. You should take oral preparations of methylnaltrexone on an empty stomach at least 30 minutes before your first meal of the day.
dolutegravir food
Applies to: Triumeq (abacavir / dolutegravir / lamivudine)
Information for this minor interaction is available on the professional version.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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