Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- estradiol topical
- Evista (raloxifene)
Interactions between your drugs
estradiol topical raloxifene
Applies to: estradiol topical, Evista (raloxifene)
GENERALLY AVOID: The concurrent use of raloxifene and systemic estrogen or hormone replacement therapy has not been evaluated in prospective clinical trials. Safety and efficacy of this combination are unknown. However, concomitant use of vaginal estrogen preparations was allowed in clinical trials for treatment of atrophic vaginal symptoms if necessary.
MANAGEMENT: Due to the lack of clinical data, use of raloxifene with systemic estrogens is not recommended.
References (1)
- (2001) "Product Information. Evista (raloxifene)." Lilly, Eli and Company
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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