Drug Interaction Report

Bile acid binding resins such as cholestyramine, colestipol, and colesevelam may interfere with the absorption of hydrocortisone and reduce its levels in the bloodstream. This may make the medication less effective in treating your condition. To minimize the possibility of interaction, it is recommended that you separate the dosing times of the bile acid binding resin and other oral medications. If you are taking cholestyramine or colestipol, you should take hydrocortisone at least 1 hour before or 4 to 6 hours after the cholestyramine or colestipol dose. If you are taking colesevelam, you should take hydrocortisone at least 4 hours before the colesevelam dose, or separate the dosing times by as much as possible if a 4 hour interval is not achievable. Talk to your doctor or pharmacist if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Cholestyramine may interfere with the absorption of certain vitamins such as A, D, E and K. Therefore, it is recommended that you take multivitamin with minerals at least 1 hour before or 4 to 6 hours after cholestyramine to minimize the risk of interaction. Talk to your doctor or pharmacist if you have questions on how to take these or other medications you are prescribed. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.