Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- Cinvanti (aprepitant)
- isavuconazonium
Interactions between your drugs
aprepitant isavuconazonium
Applies to: Cinvanti (aprepitant), isavuconazonium
MONITOR: Coadministration of isavuconazonium sulfate (prodrug of isavuconazole), a substrate as well as a moderate inhibitor of CYP450 3A4/5, with drugs that are both a substrate as well as inducer of CYP450 3A4/5 may result in decreased plasma concentrations of isavuconazole and increased plasma concentrations of the other drug. Isavuconazole may inhibit the metabolism of the coadministered drug while its own metabolism may be induced by the coadministered drug.
MANAGEMENT: Caution is advised if isavuconazonium sulfate is used concomitantly with drugs that are both a substrate and inducer of CYP450 3A4/5, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate whenever these drugs are added to or withdrawn from combination therapy.
References (4)
- (2003) "Product Information. Emend (aprepitant)." Merck & Co., Inc
- Cerner Multum, Inc. "UK Summary of Product Characteristics."
- (2008) "Product Information. Emend for Injection (fosaprepitant)." Merck & Co., Inc
- (2015) "Product Information. Cresemba (isavuconazonium)." Astellas Pharma US, Inc
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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