Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- pyrimethamine
- sodium bicarbonate / sodium citrate
Interactions between your drugs
pyrimethamine sodium bicarbonate
Applies to: pyrimethamine, sodium bicarbonate / sodium citrate
ADJUST DOSING INTERVAL: The concomitant administration of antacids or absorbent antidiarrheals may significantly reduce the bioavailability of pyrimethamine by reducing its absorption. Therapeutic failure may result.
MANAGEMENT: Antacids and antidiarrheals should be taken at least 2 to 3 hours apart from pyrimethamine.
References (1)
- Cerner Multum, Inc. "UK Summary of Product Characteristics."
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
Report options
- Switch to consumer interaction data
- Email this report to a friend, doctor, or patient
- Ask questions, find answers
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
See also:
Bactrim
Bactrim (sulfamethoxazole and trimethoprim) is an antibiotic used to treat ear infections, urinary ...
Plaquenil
Plaquenil is used to treat or prevent malaria and to treat the symptoms of rheumatoid arthritis ...
Botox
Botox is used to treat chronic migraines, excessive sweating, bladder conditions, eye muscle ...
Zithromax
Zithromax (azithromycin) treats infections caused by bacteria, such as respiratory infections, skin ...
Azithromycin Dose Pack
Azithromycin Dose Pack is used for babesiosis, bacterial endocarditis prevention, bacterial ...
Vibramycin
Vibramycin is used for acne, actinomycosis, amebiasis, anthrax, anthrax prophylaxis, bacterial ...
Cleocin
Cleocin (clindamycin) is used to treat serious bacterial infections. Includes Cleocin side effects ...
Biaxin
Biaxin is used for bacterial endocarditis prevention, bronchitis, dental abscess, helicobacter ...
SMZ-TMP DS
SMZ-TMP DS (sulfamethoxazole and trimethoprim) is an antibiotic used to treat ear infections ...
Co-trimoxazole
Co-trimoxazole is used for bacterial infection, bacterial skin infection, bronchitis ...
Learn more
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Check Interactions
To view an interaction report containing 4 (or more) medications, please sign in or create an account.
Save Interactions List
Sign in to your account to save this drug interaction list.