Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- amphotericin b cholesteryl sulfate
- digitoxin
Interactions between your drugs
digitoxin amphotericin B cholesteryl sulfate
Applies to: digitoxin, amphotericin b cholesteryl sulfate
MONITOR: Although amphotericin does not alter the pharmacokinetics of digoxin, it may increase the risk of toxicity. The mechanism is reduction of serum potassium via renal potassium wasting.
MANAGEMENT: The patient's potassium should be replenished, and serum potassium levels should be checked frequently during therapy. Electrocardiographic monitoring may also be indicated.
References (3)
- Miller R, Bates J (1969) "Amphotericin B toxicity." Ann Intern Med, 71, p. 1089-95
- Cushard WG, Kohanim M, Lantis LR (1969) "Blastomycosis of bone." J Bone Joint Surg Am, 51A, p. 704-12
- "Product Information. Abelcet (amphotericin B lipid complex)." Liposome Company Inc, The
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
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Further information
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