Drug Interaction Report

Using polyethylene glycol 3350 together with bisacodyl may increase the risk of gastrointestinal side effects such as ulcerations in the colon and ischemic colitis (an inflammatory condition caused by reduced blood flow to the colon due to narrowed or blocked blood vessels). Although these side effects are relatively rare, they may be potentially serous and life-threatening, particularly ischemic colitis. Nonetheless, certain bowel cleansing regimens given prior to a colonoscopy may require the concurrent use of a stimulant laxative such as bisacodyl in order to be fully effective. You should avoid using these medications together unless specifically recommended or prescribed by your doctor. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

The recommended maximum number of medicines in the 'osmotic laxatives' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'osmotic laxatives' category:

• polyethylene glycol 3350
• Tridate (bisacodyl / magnesium citrate)

Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.