Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- ondansetron
- Talicia (amoxicillin / omeprazole / rifabutin)
Interactions between your drugs
ondansetron rifabutin
Applies to: ondansetron, Talicia (amoxicillin / omeprazole / rifabutin)
MONITOR: Concomitant use of rifamycin derivatives with ondansetron may result in a reduced antiemetic effect, particularly after the oral administration of ondansetron. The proposed mechanism is induction of the CYP450 3A4/1A2 mediated metabolism of ondansetron.
MANAGEMENT: Patients should be monitored for reduced antiemetic effects and the ondansetron dose adjusted as necessary.
References (1)
- Villikka K, Kivisto KT, Neuvonen PJ (1999) "The effect of rifampin on the pharmacokinetics of oral and intravenous ondansetron." Clin Pharmacol Ther, 65, p. 377-81
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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