Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- Posicor (mibefradil)
- prucalopride
Interactions between your drugs
mibefradil prucalopride
Applies to: Posicor (mibefradil), prucalopride
Coadministration with inhibitors of P-glycoprotein (P-gp) may increase the plasma concentrations of prucalopride, which is thought to be a weak substrate of the efflux transporter. When given with the potent CYP450 3A4 and P-gp inhibitor, ketoconazole (200 mg twice daily), prucalopride peak plasma concentration (Cmax) and systemic exposure (AUC) increased by approximately 40%. This effect is unlikely to be clinically significant.
References (3)
- EMEA. European Medicines Agency (2007) EPARs. European Union Public Assessment Reports. http://www.ema.europa.eu/ema/index.jsp?curl=pages/includes/medicines/medicines_landingpage.jsp&mid
- Cerner Multum, Inc. "Australian Product Information."
- (2012) "Product Information. Resotran (prucalopride)." Janssen Pharmaceuticals
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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