Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- Depo Provera (medroxyprogesterone)
- teriflunomide
Interactions between your drugs
medroxyPROGESTERone teriflunomide
Applies to: Depo Provera (medroxyprogesterone), teriflunomide
MONITOR: Coadministration with teriflunomide may increase the plasma concentrations of contraceptive hormones. The mechanism of interaction has not been described. In study subjects, ethinyl estradiol peak plasma concentration (Cmax) and systemic exposure (AUC) increased by approximately 1.5-fold each, and levonorgestrel Cmax and AUC increased by approximately 1.3- and 1.4-fold, respectively, following repeated doses of teriflunomide.
MANAGEMENT: Caution is advised if teriflunomide is prescribed in patients receiving hormonal contraceptives due to the potential for increased adverse effects such as thromboembolism. Consideration should be given to the type or dose of contraceptives used in combination with teriflunomide.
References (1)
- (2012) "Product Information. Aubagio (teriflunomide)." Genzyme Corporation
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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