Drug Interaction Report

ADDITIONAL CONTRACEPTION RECOMMENDED: Sugammadex may decrease the free plasma concentrations and therapeutic efficacy of hormonal contraceptives. In vitro binding studies indicate that sugammadex can bind to progestogen. Sugammadex 4 mg/kg is predicted to reduce progestogen systemic exposure (AUC) by 34%. The predicted effect is lower for estrogens. According to the manufacturer, the administration of a bolus dose of sugammadex may result in reduced contraceptive effectiveness equivalent to a missed dose of the contraceptive. Clinical data have not been reported.

MANAGEMENT: Female patients of reproductive potential receiving hormonal contraceptives (whether oral or non-oral) should use an additional, nonhormonal contraceptive method or backup method of contraception (e.g., condoms and spermicides) for 7 days after sugammadex administration.